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KMID : 0363220090470030343
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Korean Journal of Dermatology
2009 Volume.47 No. 3 p.343 ~ p.346
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A Case of Recalcitrant Pyoderma Gangrenosum Treated by Infliximab
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Jung Hong-Dae
Chi Seong-Geun
Kim Byung-Soo
Lee Weon-Ju
Lee Seok-Jong
Kim Do-Won
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Abstract
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Pyoderma gangrenosum is an uncommon, neutrophilic, ulcerating, chronic dermatosis with obscure etiology. Many
therapeutic modalities have been used in the past, but they have not always provided favorable outcomes. Recently,
tumor necrosis factor-α inhibitors have been gaining attention in the treatment of recalcitrant pyoderma gangrenosum. A 57-year-old woman presented with painful, recurrent erythematous nodules and ulcers on both legs. She had been treated with systemic steroids, immunosuppressants, dapsone, and colchicine, and she experienced improvement with systemic steroids only. After using infliximab (5 mg/kg), she experienced dramatic improvement in her lesions. Thus, we report a recalcitrant case of pyoderma gangrenosum that was successfully treated with infliximab.
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KEYWORD
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Infliximab, Pyoderma gangrenosum
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